San Antonio has no shortage of fertility clinics, but few can claim what the Fertility Center of San Antonio has built over more than 38 years: a deeply rooted, independently owned reproductive endocrinology practice staffed by two board-certified REIs who have collectively spent the better part of their careers treating San Antonio families. With a 4.7-star rating from 454 verified reviewers, this clinic earns its reputation the old-fashioned way — through continuity of care and clinical depth that a corporate network rarely replicates.
The Physicians: Military Training, Ivy League Fellowships, Deep San Antonio Roots
The Fertility Center of San Antonio was founded by Dr. Joseph E. Martin and has since grown around two full-time reproductive endocrinologists whose credentials are exceptional by any measure.
Dr. Gregory S. Neal, M.D., FACOG completed his M.D. at Texas A&M College of Medicine, trained through the U.S. Air Force at Wilford Hall Medical Center in San Antonio, and then completed a fellowship in reproductive endocrinology and infertility at New York Hospital-Cornell Medical Center in 1994. Board certified in both REI and OB-GYN, he is a member of ASRM and SART. Texas Monthly has recognized him as a Texas Super Doctor for more than fifteen consecutive years — earning him a place in the Super Doctors Hall of Fame Legacy program.
Dr. Matthew G. Retzloff, M.D., FACOG holds a B.S. from the U.S. Air Force Academy and an M.D. from the University of Texas Southwestern Medical Center, and completed a fellowship in reproductive endocrinology at Brigham and Women's Hospital, Harvard Medical School in 2003. He went on to direct the Air Force's IVF program before retiring after nearly 21 years of active duty service and joining this practice in 2014. His peer-reviewed research appears in Fertility and Sterility and Obstetrics and Gynecology, and he has served on the SART Executive Council as a representative for U.S. IVF physicians.
Nicole Gonzalez, PA-C rounds out the clinical team. All physicians and nurses have been on staff for at least five years — stability that distinguishes this practice from high-volume chains where provider turnover is routine.
Services: A Full REI Practice in an Independent Setting
The Fertility Center of San Antonio offers the full spectrum of reproductive endocrinology, from basic infertility workups through advanced genetic testing and minimally invasive surgery.
IUI is available for ovulatory dysfunction, mild male factor infertility, and unexplained infertility, serving as a logical first step before escalating to IVF. Standard IVF with fresh or frozen embryo transfer is the clinical backbone, supported by ICSI and laser-assisted hatching for patients with prior implantation failures.
Preimplantation Genetic Testing is a notable strength: the clinic became the first in Texas to offer PGD in 2005. Today that includes PGT-A (chromosomal screening) and PGT-M (monogenic disorder testing), giving patients with hereditary conditions or recurrent pregnancy loss a data-driven path to embryo selection.
Donor sperm IVF serves single women, lesbian couples, and any patient requiring donor gametes. Male factor infertility is addressed in-house through semen analysis and treatment coordination. Tubal reversal surgery is also offered, with reported pregnancy rates of 40%–80% depending on tubal length and the number of tubes reversed.
Nature's IVF: A Genuinely Differentiated Offering
One of the most distinctive services at the Fertility Center of San Antonio is Nature's IVF, a procedure utilizing INVOcell technology. In conventional IVF, fertilized embryos spend their first five days in a laboratory incubator. In Nature's IVF, that incubation happens inside the woman's own vaginal canal — a small cylindrical INVOcell device, approximately four centimeters long, holds the eggs and sperm and is inserted after retrieval. The body's natural temperature regulation, oxygen ratios, and pH balance support fertilization and early embryo development, after which the device is removed and the best-quality embryo is transferred to the uterus.
The cost advantage is real: $5,900 per attempt at this clinic versus $12,000–$20,000 for conventional IVF. A 2016 study found Nature's IVF achieved a 55% live birth rate compared to approximately 60% for traditional IVF — a modest trade-off that many patients find worthwhile. Pregnancy rates are three to five times higher than IUI, making it a compelling middle-ground option.
The clinic also offers the Precision IVF Refund Program, a shared-risk structure for patients who pursue multiple IVF cycles without a successful pregnancy. In Texas — which has no fertility insurance mandate — tools like this are not ancillary; they are the financial backbone of treatment planning for most patients. Understanding how fertility insurance coverage varies by state should be an early step before committing to any cycle.
Outcomes and SART Reporting
The Fertility Center of San Antonio reports its outcomes to SART as required of member clinics. The clinic-published figures show an overall live birth rate of 22.4% across all patient ages. Stratified by age — the more meaningful comparison — patients under 35 achieved a 41.4% live birth rate; the 38–40 age group reached 22.3%. These figures align with national trends; for a deeper breakdown by age cohort, Fertlo's IVF success rates by age guide provides useful context for setting realistic expectations.
How This Clinic Differs from Aspire Fertility in San Antonio
San Antonio patients will likely encounter Aspire Fertility, which operates under the Prelude Network — the largest fertility chain in the U.S., with 36-plus locations. Aspire San Antonio (formerly RMA of Texas) reports 6.3 births per 10 transfers (top 17% nationally) and has four REIs on its team.
The Fertility Center of San Antonio is a different kind of practice. Independently owned, its medical culture was shaped by two physicians who built careers in the Air Force and academic medicine before settling permanently in San Antonio. Patients work directly with Dr. Neal or Dr. Retzloff — the same physician from initial evaluation through retrieval and transfer. The clinic's deliberate emphasis on privacy and personal attention reflects its positioning as a counterpoint to high-throughput environments.
Neither clinic is universally superior. Fertlo's guide on how to choose a fertility clinic walks through the key factors — lab accreditation, physician availability, cycle management protocols — that should inform that decision.
Texas Context: No Insurance Mandate
Texas has no law requiring insurers to cover infertility treatment, so most San Antonio patients pay out of pocket. The Fertility Center's $5,900 Nature's IVF and its Precision IVF Refund Program exist precisely to manage that exposure. Fertlo's IVF cost by state resource offers current pricing data and notes what is typically excluded from quoted cycle costs — including medications, which often add $3,000–$6,000 per cycle. Patients browsing Texas fertility clinics should factor that in from the start.
Considering At-Home Insemination?
Not every fertility journey begins in a clinic. At-home intracervical insemination (ICI) is a lower-cost, private option that suits patients with no known fertility diagnosis — including single parents by choice, same-sex couples, and people who want to try a few cycles before committing to clinical treatment.
At-home insemination kits like those from MakeAMom come with step-by-step instructions designed for donor or partner sperm. Kits are a one-time purchase that can be reused until conception succeeds, require no clinic visit, and arrive in plain, discreet packaging. Many patients use them as a first step while working toward a fertility consultation — or alongside ovulation tracking while they wait for an appointment slot.
If you have a known fertility diagnosis, have been trying for 12 months without success (six months if you're over 35), or your physician has already recommended IUI or IVF, a board-certified reproductive endocrinologist is the right next step.
Frequently Asked Questions
What makes the Fertility Center of San Antonio different from larger fertility networks like Aspire Fertility?
The Fertility Center is independently owned, and patients work with the same two REIs — Dr. Neal and Dr. Retzloff — from consultation through embryo transfer. Large networks like Aspire (part of the 36-location Prelude Network) offer strong outcomes data and multiple site locations, but physician continuity can vary. For patients who place high value on seeing the same doctor at every appointment, this independent practice is structured specifically for that experience.
Does the Fertility Center of San Antonio offer fertility care for LGBTQ+ patients?
Yes. The clinic offers explicit LGBTQ family planning services. Same-sex female couples can pursue IVF with donor sperm, including reciprocal IVF, where one partner's eggs are fertilized and transferred to the other. Male couples and single men can receive consultation on embryo creation toward a gestational carrier arrangement. The clinic's experience with donor-gamete cycles means these are established protocols, not edge cases.
How much does IVF cost at the Fertility Center of San Antonio, and does Texas insurance cover it?
Nature's IVF with INVOcell starts at $5,900 per attempt — well below the $12,000–$20,000 range for conventional IVF in the San Antonio market before medications. Texas has no fertility insurance mandate, so most commercial plans exclude IVF. The clinic participates with Progyny for employer-sponsored benefits, and the Precision IVF Refund Program provides shared-risk financing for multi-cycle patients. Reviewing fertility insurance options by state before your first consultation will clarify what your specific plan covers.